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KMID : 0359819940230080859
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Journal of Korean Neurosurgical Society
1994 Volume.23 No. 8 p.859 ~ p.869
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The Influence of Blood Glucose Change on Dopamine, Norepinephrine and Serotonin Concentration in the Frontal Lobe, Hippocampus and Striatum of Transient Ischemic Rats's Brain
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김봉룡
박정률/박윤관/정홍섭/이기찬/이훈갑
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Abstract
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Hyperglycemia during either global or regional ischemia is widely known to be detrimental, and ischemia induced release of diverse neurotransmitters and the ensuing activation of specific postsynaptic receptors have been suggested to play a
important
role in the development of ischemic selective vulunerability. This study was undertaken to investigate the influence of blood glucose change on tissue concentration of some catecholamines ; dopamine, norepinephrine, serotonin, of the transient
ischemic
rat's brain, estimated by high performance liquid chromatography (HPLC) assay system, following transient bilateral forebrain ischemia in the rat's model subjected to 20 minutes of normothermic ischemia by two vesseles occulusion plus profound
hypotension. Norepinephrine, dopamine and serotonin levels were measured in the frontal cortex, hippocampus and striatum respectively by HPLC. The concentrations of catecholamines were significantly decreased in all sampled areas ion experimental
groups
compared with the control group (p<0.05), respectively (average decrease rate : norepinephrine 71%, dopamine 89%, serotonin 80% in frontal cortex ; norepinephrine 71%, dopamine 93%, serotonin 81% in hippocampus ; norepinephrine 33%, dopamine 35%,
and
serotonin 78% in striatum). Dopamine was relatively decreased in concentration in frontal cortex and hippocampus, and serotonin was relatively decreased in striatum. But no statistic significancy (p>0.05) of catecholamines level between each
experimental group (hyper-, hypo- and normoglycemic group) according to the change of blood sugar. The results suggested that blood glucose level did not influence the tissue concentration of dopamine, norepinephrine and serotonin in fronal
cortex,
hippocampus and striatum of transient ischemic rat's brain.
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KEYWORD
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